The city of Poplar Bluff is located in southeast Missouri, just 17 miles north of the Arkansas state line at the intersection of highway 67 and highway 60 on the banks of the Black River.
Main attraction in the city include the Margaret Harwell Art Museum, the Bloodworth House, Moark Regional Railroad Museum, Poplar Bluff Historical Museum, Lake Wappapello and Mark Twain National Forest.
Hotels and motels in Poplar Bluff are located at the intersection of highway 67 and highway 60, within 3 miles of downtown.
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